What is the active site in an enzyme-receptor context, and why is it significant?

• A. It is the region where the substrate binds and its unique shape/chemistry confers high specificity.
• B. It is the site where water is released after the reaction.
• C. It is the site for allosteric modulators bind.
• D. It is the pocket used for docking inhibitors regardless of substrate.

Answer: (B)