Allosteric binding can modulate receptor function. Which statement best describes this?

• A. Allosteric binding can modulate function by changing shape when bound by other ligands.
• B. Allosteric binding directly activates the receptor as orthosteric ligands do.
• C. Allosteric binding always blocks signaling.
• D. Allosteric binding occurs at the same site as the endogenous ligand.

Answer: (A)